Vinyl chloride: the carcinogenic risk.
نویسندگان
چکیده
منابع مشابه
Risk Assessment of Exposure to Vinyl Chloride
Carcinogenic risk estimation of human exposure to vinyl chloride (VC) was determined by utilizing laboratory animal data on the chronic bioassay of VC, VC pharmacokinetics and VC macromolecular interaction. The impact of these data upon the type of risk VC may pose to humans and the selection of appropriate mathematical models to quantitatively estimate "risk" are discussed. The problem of esti...
متن کاملWorker exposure to vinyl chloride and poly(vinyl chloride).
The National Institute for Occupational Safety and Health (NIOSH) in early 1974 began industrial hygiene studies of vinyl chloride exposed workers. Three VC monomer plants, three VC polymerization plants, and seven PVC fabrication plants were surveyed. V polymerization plant workers and workers in one job category in VC monomer plants were exposed to average levels above 1 ppm. The highest aver...
متن کاملVinyl chloride Toxicological overview
Vinyl chloride is readily and rapidly absorbed via inhalation, ingestion and through the skin At room temperature vinyl chloride is a gas, so inhalation is the major route exposure Following absorption, it is distributed through the body, with the highest concentrations found in the liver and kidneys, followed by the lungs and spleen Vinyl chloride is mainly metabolised in the liver int...
متن کاملVinyl Chloride General information
Toxic by all routes of exposure – inhalation, ingestion, skin contact Carcinogenic in humans Inhalation of vinyl chloride causes coughing, wheezing and breathlessness, headache, ataxia, drowsiness and coma Ingestion of vinyl chloride causes nausea, vomiting, diarrhoea, abdominal pain, and haematemesis may occur. Skin contact causes irritation, pain, burns and contact dermatitis. Rapid...
متن کاملNeoplastic risk among workers exposed to vinyl chloride.
As early as 1930 the first adverse health effects of vinyl chloride (VC) were reported.' Since then, numerous observations and studies have indicated a wide range of toxicity attributable to the effects of VC on the central nervous system, the liver, the bones of the fingers, and the Lately, the spectrum of known toxic effects of VC broadened to include malignant neoplasms. Viola et al.," in 19...
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ژورنال
عنوان ژورنال: BMJ
سال: 1976
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.6039.815-a